Dehydroepiandrosterone suppresses the elevated hepatic glucose-6-phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: comparison with troglitazone.

@article{Aoki1999DehydroepiandrosteroneST,
  title={Dehydroepiandrosterone suppresses the elevated hepatic glucose-6-phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: comparison with troglitazone.},
  author={K. Aoki and Takamoto Saito and Shinobu Satoh and Koji Mukasa and Morishige Kaneshiro and Sumitada Kawasaki and Atushi Okamura and Hisahiko Sekihara},
  journal={Diabetes},
  year={1999},
  volume={48 8},
  pages={
          1579-85
        }
}
The effect of dehydroepiandrosterone (DHEA) on the hepatic and muscle glucose metabolizing enzymes and on blood glucose were investigated in insulin-resistant diabetic C57BL/KsJ-db/db mice and their heterozygote littermates (db/+m). The results were compared with those after troglitazone administration under the same conditions. Despite hyperinsulinemia, hepatic glucose-6-phosphatase (G6Pase) and fructose-1,6-bisphosphatase (FBPase) activities are higher in db/db than in db/+m mice. Dietary… CONTINUE READING

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