Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension.


Current therapy of pulmonary arterial hypertension (PAH) is inadequate. Dehydroepiandrosterone (DHEA) effectively treats experimental pulmonary hypertension in chronically hypoxic and monocrotaline-injected rats. Contrary to these animal models, SU5416/hypoxia/normoxia-exposed rats develop a more severe form of occlusive pulmonary arteriopathy and right… (More)
DOI: 10.1152/ajpheart.00746.2012


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