Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors.

@article{Iruthayanathan2005DehydroepiandrosteroneRO,
  title={Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors.},
  author={Mary Iruthayanathan and Y. Zhou and G. Childs},
  journal={Endocrinology},
  year={2005},
  volume={146 12},
  pages={
          5176-87
        }
}
  • Mary Iruthayanathan, Y. Zhou, G. Childs
  • Published 2005
  • Biology, Medicine
  • Endocrinology
  • A decline in dehydroepiandrosterone (DHEA) and GH levels with aging may be associated with frailty and morbidity. Little is known about the direct effects of DHEA on somatotropes. We recently reported that 17beta-estradiol (E2), a DHEA metabolite, stimulates the expression of GH in vitro in young female rats. To test the hypothesis that DHEA restores function in aging somatotropes, dispersed anterior pituitary (AP) cells from middle-aged (12-14 months) or young (3-4 months) female rats were… CONTINUE READING
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