Dehydroepiandrosterone reduces accumulation of lipid droplets in primary chicken hepatocytes by biotransformation mediated via the cAMP/PKA-ERK1/2 signaling pathway.

@article{Li2018DehydroepiandrosteroneRA,
  title={Dehydroepiandrosterone reduces accumulation of lipid droplets in primary chicken hepatocytes by biotransformation mediated via the cAMP/PKA-ERK1/2 signaling pathway.},
  author={Longlong Li and Chongyang Ge and Dian Wang and Lei Yu and Jinlong Zhao and Haitian Ma},
  journal={Biochimica et biophysica acta. Molecular and cell biology of lipids},
  year={2018},
  volume={1863 6},
  pages={
          625-638
        }
}
Dehydroepiandrosterone (DHEA) is commonly used as a nutritional supplement to control fat deposition, but the mechanism of this action is poorly understood. In this study, we demonstrated that DHEA increased phosphorylation of AMP-activated protein kinase (p-AMPK). Elevated p-AMPK levels resulted in reduced expression of sterol regulatory element binding protein-1c, acetyl CoA carboxylase, fatty acid synthase and enhanced expression of peroxisome proliferators-activated receptor α and carnitine… CONTINUE READING