Dehydroepiandrosterone inhibits the expression of carcinogen-activating enzymes in vivo.

@article{Ciolino2003DehydroepiandrosteroneIT,
  title={Dehydroepiandrosterone inhibits the expression of carcinogen-activating enzymes in vivo.},
  author={Henry P. Ciolino and C R Macdonald and Omar S Memon and Maame Dankwah and Grace Chao Yeh},
  journal={International journal of cancer},
  year={2003},
  volume={105 3},
  pages={321-5}
}
We investigated the effect of the steroid hormone dehydroepiandrosterone (DHEA) on the hepatic expression and activity of carcinogen-activating enzymes, the cytochromes P450 (CYP) 1A1, 1A2 and 1B1, in Sprague-Dawley rats. In animals fed DHEA at 200 or 400 mg/kg body weight every other day for 2 weeks prior to exposure to the aryl hydrocarbon dimethylbenz[a]anthracene (DMBA, 5 mg/kg), there was a dose-dependent decrease in hepatic CYP activity, as measured by ethoxyresorufin-O (EROD) assay, from… CONTINUE READING