Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway.

@article{Sun2010DehydroepiandrosteroneinducedPO,
  title={Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway.},
  author={Hongzhi Sun and Tong-Wei Yang and Wei-Jin Zang and ShuFang Wu},
  journal={The Journal of endocrinology},
  year={2010},
  volume={204 3},
  pages={
          311-8
        }
}
Dehydroepiandrosterone (DHEA) is an endogenous steroid that is metabolized to androgens and/or estrogens in the human prostate. DHEA levels decline with age, and use of DHEA supplements to retard the aging process is of unproved effectiveness and safety. In this study, rat ventral prostatic epithelial cells were used to determine whether DHEA-modulated proliferation and prostate-specific antigen (PSA listed as KLKB1 in the MGI Database) production were mediated via the androgen receptor (AR… CONTINUE READING

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