Dehydroepiandrosterone as a regulator of immune cell function.

  title={Dehydroepiandrosterone as a regulator of immune cell function.},
  author={Jon Hazeldine and Wiebke Arlt and Janet M. Lord},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={120 2-3},
Dehydroepiandrosterone (DHEA) is a C19 steroid of adrenal origin. Notably, its secretion declines with age, a phenomenon referred to as the "adrenopause". For many years, the physiological significance of DHEA remained elusive. However, many studies have now shown that DHEA has significant immune modulatory function, exhibiting both immune stimulatory and anti-glucocorticoid effects. Although several of these studies are limited by the fact that they were carried out in rodents, who are… CONTINUE READING


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