Dehydroepiandrosterone and its metabolites: Differential effects on androgen receptor trafficking and transcriptional activity

@article{Mo2006DehydroepiandrosteroneAI,
  title={Dehydroepiandrosterone and its metabolites: Differential effects on androgen receptor trafficking and transcriptional activity},
  author={Qianxing Mo and Shi-fang Lu and Neal G. Simon},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2006},
  volume={99},
  pages={50-58}
}
  • Q. Mo, Shi-fang Lu, N. Simon
  • Published 1 April 2006
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
View on Elsevier
doi.org
98 Citations
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2
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34
Methods Citations
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98 Citations

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Effects of CYP7B1-related steroids on androgen receptor activation in different cell lines.
Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEA-S) in Mammalian Reproduction: Known Roles and Novel Paradigms.
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Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARalpha in rodents.
Effects of vitamin D as a regulator of androgen intracrinology in LNCAP prostate cancer cells.
The effect of dehydroepiandrosterone (DHEA) on renal function and metabolism in diabetic rats
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References

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DHEA and DHEA sulfate differentially regulate neural androgen receptor and its transcriptional activity.
Dehydroepiandrosterone upregulates neural androgen receptor level and transcriptional activity.
TLDR
The findings suggest that the mechanism of action of DHEA in the brain can involve a "crosstalk" cellular signaling system that involves both nongenomic and genomic components.
Evidence that dehydroepiandrosterone, DHEA, directly inhibits GnRH gene expression in GT1–7 hypothalamic neurons
Androgen therapy with dehydroepiandrosterone
  • J. Buvat
  • Medicine, Biology
    World Journal of Urology
  • 2003
TLDR
The present data do not exclude a role of DHEA in other conditions, but this remains to be properly established, and practical considerations on dosage to be used, contraindications and follow-up are included.
Pharmacology And Therapeutic Effects of Dehydroepiandrosterone In Older Subjects
TLDR
There is no scientific evidence to recommend DHEA replacement in the elderly, and further studies are needed to form conclusions about the efficacy and the safety of DHEa replacement in elderly and to better understand the mechanisms of action of D HEA at the molecular and cellular levels.
Dehydroepiandrosterone: is there a role for replacement?
TLDR
Human studies suggest a potential role for DHEA replacement in persons who have undergone adrenalectomy and possibly in the aging population, however, long-term studies assessing the benefits vs adverse effects must be done before D HEA replacement can be recommended.
Metabolism of dehydroepiandrosterone by rat hippocampal cells in culture: possible role of aromatization and 7-hydroxylation in neuroprotection
Dehydroepiandrosterone (DHEA) and the aging brain: flipping a coin in the "fountain of youth".
TLDR
The effect of neurosteroids, in particular DHEA, on neurochemical mechanism involved in memory and learning will be described and a novel effect on a signal transduction mechanism involving a classical "cognitive kinase" such as protein kinase C will be focused on.
Predominant androgenic component in the stimulatory effect of dehydroepiandrosterone on bone mineral density in the rat.
TLDR
The present data indicate that the potent stimulatory effect of DHEA on bone in the rat is mainly due to the local formation of androgens in bone cells and their intracrine action in osteoblasts.
Effects of Dehydroepiandrosterone on Bone Mineral Density
TLDR
More studies are needed to fully define the potential utility of DHEA replacement as an anabolic intervention for age-related osteoporosis, and further investigations are particularly warranted because prasterone is available over-the-counter in many countries and many older individuals are taking this hormone, without medical supervision, for its purported anti-aging properties.
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