Dehydroepiandrosterone and its metabolites: Differential effects on androgen receptor trafficking and transcriptional activity

  title={Dehydroepiandrosterone and its metabolites: Differential effects on androgen receptor trafficking and transcriptional activity},
  author={Qianxing Mo and Shi-fang Lu and Neal G. Simon},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • Q. Mo, Shi-fang Lu, N. Simon
  • Published 1 April 2006
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
Effects of DHEA on metabolic and endocrine functions of adipose tissue
DHEA has been shown to modulate insulin signaling pathways, enhance glucose uptake in adipocytes, and increase insulin sensitivity in patients with DHEA deficiency or abnormal glucose tolerance; it may also protect against obesity by lowering the activity of stearoyl-CoA desaturase 1 in fat cells.


Dehydroepiandrosterone upregulates neural androgen receptor level and transcriptional activity.
The findings suggest that the mechanism of action of DHEA in the brain can involve a "crosstalk" cellular signaling system that involves both nongenomic and genomic components.
Androgen therapy with dehydroepiandrosterone
  • J. Buvat
  • Medicine, Biology
    World Journal of Urology
  • 2003
The present data do not exclude a role of DHEA in other conditions, but this remains to be properly established, and practical considerations on dosage to be used, contraindications and follow-up are included.
Pharmacology And Therapeutic Effects of Dehydroepiandrosterone In Older Subjects
There is no scientific evidence to recommend DHEA replacement in the elderly, and further studies are needed to form conclusions about the efficacy and the safety of DHEa replacement in elderly and to better understand the mechanisms of action of D HEA at the molecular and cellular levels.
Dehydroepiandrosterone: is there a role for replacement?
Human studies suggest a potential role for DHEA replacement in persons who have undergone adrenalectomy and possibly in the aging population, however, long-term studies assessing the benefits vs adverse effects must be done before D HEA replacement can be recommended.
Dehydroepiandrosterone (DHEA) and the aging brain: flipping a coin in the "fountain of youth".
The effect of neurosteroids, in particular DHEA, on neurochemical mechanism involved in memory and learning will be described and a novel effect on a signal transduction mechanism involving a classical "cognitive kinase" such as protein kinase C will be focused on.
Predominant androgenic component in the stimulatory effect of dehydroepiandrosterone on bone mineral density in the rat.
The present data indicate that the potent stimulatory effect of DHEA on bone in the rat is mainly due to the local formation of androgens in bone cells and their intracrine action in osteoblasts.
Effects of Dehydroepiandrosterone on Bone Mineral Density
More studies are needed to fully define the potential utility of DHEA replacement as an anabolic intervention for age-related osteoporosis, and further investigations are particularly warranted because prasterone is available over-the-counter in many countries and many older individuals are taking this hormone, without medical supervision, for its purported anti-aging properties.