Dehydroepiandrosterone activates 5'-adenosine monophosphate-activated protein kinase and suppresses lipid accumulation and adipocyte differentiation in 3T3-L1 cells.

@article{Yokokawa2020DehydroepiandrosteroneA5,
  title={Dehydroepiandrosterone activates 5'-adenosine monophosphate-activated protein kinase and suppresses lipid accumulation and adipocyte differentiation in 3T3-L1 cells.},
  author={Takumi Yokokawa and Koji Sato and Ryoko Narusawa and K. Kido and Risako Mori and N. Iwanaka and T. Hayashi and T. Hashimoto},
  journal={Biochemical and biophysical research communications},
  year={2020}
}
  • Takumi Yokokawa, Koji Sato, +5 authors T. Hashimoto
  • Published 2020
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • Substantial evidence has linked dehydroepiandrosterone (DHEA) levels to the anti-obesity and anti-diabetic effects of exercise. While 5'-adenosine monophosphate-activated protein kinase (AMPK) is a negative regulator of adipocyte differentiation and lipid accumulation, activation of mammalian target of rapamycin complex 1 (mTORC1), which is inhibited by AMPK, is required for adipocyte differentiation and positively regulates lipid accumulation. DHEA treatment activates the AMPK pathway in C2C12… CONTINUE READING