Dehydroepiandrosterone Sulfate and-Cell Function Enhanced Glucose-Induced Insulin Secretion and Altered Gene Expression in Rodent Pancreatic-Cells

Abstract

Administration of dehydroepiandrosterone (DHEA), or its sulfated form (DHEAS), controls hyperglycemia in diabetic rodents without directly altering insulin sensitivity. We show that DHEAS enhanced glucose-stimulated insulin secretion when administered in vivo to rats or in vitro to -cell lines, without changing cellular insulin content. Insulin secretion… (More)

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