Dehydroepiandrosterone (DHEA): Hypes and Hopes

  title={Dehydroepiandrosterone (DHEA): Hypes and Hopes},
  author={Krzysztof Rutkowski and Paweł Sowa and Joanna Rutkowska-Talipska and Anna Kuryliszyn-Moskal and Ryszard Rutkowski},
Dehydroepiandrosterone (DHEA) and its sulfated form dehydroepiandrosterone sulfate (DHEAS) are the most abundant circulating steroid hormones in humans. In animal studies, their low levels have been associated with age-related involuntary changes, including reduced lifespan. Extrapolation of animal data to humans turned DHEA into a ‘superhormone’ and an ‘anti-aging’ panacea. It has been aggressively marketed and sold in large quantities as a dietary supplement. Recent double-blind, placebo… 

Should Dehydroepiandrosterone be administered to women?

Data support small benefits in quality of life and mood but not for anxiety or sexual function in women with primary or secondary adrenal insufficiency or anorexia, and no consistent beneficial effects of DHEA administration have been observed for menopausal symptoms, sexual function, cognition, or overall wellbeing in normal women.

The Immunoregulatory Actions of DHEA in Tuberculosis, A Tool for Therapeutic Intervention?

Data recorded from TB patients, mouse models, or in vitro studies show that DHEA is likely to be implied in better disease control, and this provides a stimulating background for carrying out clinical studies aimed at assessing the usefulness of D HEA as an adjuvant in TB patients.

Dehydroepiandrosterone: Molecular mechanisms and therapeutic implications in osteoarthritis

  • Kai HuangLi-Dong Wu
  • Biology, Medicine
    The Journal of Steroid Biochemistry and Molecular Biology
  • 2018

Effect of dehydroepiandrosterone on the liver of perimenopausal rat: multiple doses study

Long-term administration of high doses of DHEA causes ultrastructural alterations and changes in the levels of cholesterol and triglyceride in hepatocytes of perimenopausal rats.

DHEA in bone: the role in osteoporosis and fracture healing

The aim of this review is to discuss the history and mechanisms of DHEA as they relate to the skeletal system, and to evaluate if D HEA has any role in treating fractures.

Effect of dehydroepiandrosterone on atherosclerosis in postmenopausal women.

DHEA has great value in preventing AS and inhibiting its progression in postmenopausal women by countering these mechanisms, which include regulating the blood lipid status, protecting ECs and coping with oxidative stress and inflammatory reactions of the vascular endothelium.

Precipitous Dehydroepiandrosterone Declines Reflect Decreased Physical Vitality and Function

  • D. RendinaC. RyffC. Coe
  • Medicine
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2017
DHEA-S and DHEA below age-expected levels were associated with more chronic illness conditions and self-reported persistent pain and pain sensitivity upon manual palpation, suggesting a more precipitous decline is already indicative of reduced vigor and physical strength by middle age.

Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women - position statement of expert panel of Polish Menopause and Andropause Society.

It is concluded that currently available clinical trials and meta-analyses indicate that DHEA supplementation is effective in women with adrenal insufficiency and chronically treated with exogenous glucocorticoids, postmenopausal women with low bone mineral density and/or osteoporosis, premenopausalWomen with sexual disorders and low libido, and in Women with vulvovaginal atrophy due to menopause or genitourinary syndrome ofMenopause.



DHEA treatment: myth or reality?

Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue.

A number of biological indices confirmed the lack of harmful consequences of this 50 mg/day DHEA administration over one year, indicating that this kind of replacement therapy normalized some effects of aging, but does not create "supermen/women" (doping).

Dehydroepiandrosterone: Biological Effects and Clinical Significance

Animal and laboratory data indicate that administration of DHEA may prevent obesity, diabetes, cancer (breast, colon and liver), and heart disease; enhance the functioning of the immune system; and prolong life; and it is therefore important that this hormone be used with care.

Dehydroepiandrosterone, the endothelium, and cardiovascular protection.

It is shown that DHEA acts as a survival factor for vascular endothelial cells, a point of departure for some of the reported beneficial actions of D HEA on the vascular system and may provide a rationale for the epidemiological linkage of DHEa and cardiovascular disease.

Dehydroepiandrosterone (DHEA)--a precursor steroid or an active hormone in human physiology.

DHEA modulates endothelial function, reduces inflammation, improves insulin sensitivity, blood flow, cellular immunity, body composition, bone metabolism, sexual function, and physical strength in frailty and provides neuroprotection, improves cognitive function,and memory enhancement.

DHEA and DHEA‐S: A Review

DHEA and DHEA‐S concentrations as they relate to stress, central nervous system function and psychiatric disorders, insulin sensitivity, immunological function, and cardiovascular disorders are addressed.

Dehydroepiandrosterone: is there a role for replacement?

Human studies suggest a potential role for DHEA replacement in persons who have undergone adrenalectomy and possibly in the aging population, however, long-term studies assessing the benefits vs adverse effects must be done before D HEA replacement can be recommended.

Role of DHEA in cardiovascular diseases.

DHEAS as a new diagnostic tool.

  • W. Leowattana
  • Medicine, Biology
    Clinica chimica acta; international journal of clinical chemistry
  • 2004

Dehydroepiandrosterone - is the fountain of youth drying out?

This article tries to summarize some of the most important facts achieved recently on the role of exogenous DHEA in health, disease and human well-being.