Dehydroepiandrosterone (DHEA): Hypes and Hopes

@article{Rutkowski2014DehydroepiandrosteroneH,
  title={Dehydroepiandrosterone (DHEA): Hypes and Hopes},
  author={Krzysztof Rutkowski and Paweł Sowa and Joanna Rutkowska-Talipska and Anna Kuryliszyn-Moskal and Ryszard Rutkowski},
  journal={Drugs},
  year={2014},
  volume={74},
  pages={1195-1207}
}
Dehydroepiandrosterone (DHEA) and its sulfated form dehydroepiandrosterone sulfate (DHEAS) are the most abundant circulating steroid hormones in humans. In animal studies, their low levels have been associated with age-related involuntary changes, including reduced lifespan. Extrapolation of animal data to humans turned DHEA into a ‘superhormone’ and an ‘anti-aging’ panacea. It has been aggressively marketed and sold in large quantities as a dietary supplement. Recent double-blind, placebo… 

Should Dehydroepiandrosterone be administered to women?

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Data recorded from TB patients, mouse models, or in vitro studies show that DHEA is likely to be implied in better disease control, and this provides a stimulating background for carrying out clinical studies aimed at assessing the usefulness of D HEA as an adjuvant in TB patients.

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Long-term administration of high doses of DHEA causes ultrastructural alterations and changes in the levels of cholesterol and triglyceride in hepatocytes of perimenopausal rats.

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Supplementation of dehydroepiandrosterone (DHEA) in pre- and postmenopausal women - position statement of expert panel of Polish Menopause and Andropause Society.

It is concluded that currently available clinical trials and meta-analyses indicate that DHEA supplementation is effective in women with adrenal insufficiency and chronically treated with exogenous glucocorticoids, postmenopausal women with low bone mineral density and/or osteoporosis, premenopausalWomen with sexual disorders and low libido, and in Women with vulvovaginal atrophy due to menopause or genitourinary syndrome ofMenopause.
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This article tries to summarize some of the most important facts achieved recently on the role of exogenous DHEA in health, disease and human well-being.
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