Dehydroepiandrosterone – a neurosteroid

  title={Dehydroepiandrosterone – a neurosteroid},
  author={Elisabeth Friess and Thomas Schiffelholz and Thomas Steckler and Arthur Steiger},
  journal={European Journal of Clinical Investigation},
Dehydroepiandrosteone (DHEA) and its sulfate ester (DHEAS) are the major secretory products of the human adrenal glands and serve as precursors for both androgenic and estrogenic steroids. DHEA/S concentrations are particularly high in the brain, and DHEA/S and related steroids can be synthesized de novo in brain glial cells. Therefore, the term ‘neurosteroids’ has been coined for these compounds. 
DHEA and Sport
  • B. Corrigan
  • Biology
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
  • 2002
DHEA was enthusiastically labelled by some as a fountain of youth or an antidote to aging that would prove to be the panacea they are seeking, and was taken up enthusiastically by the athletic community and used as a prohormone in the belief or hope that it would be converted mainly to testosterone in the body.
Adrenal Androgens Impact on Neurosteroids
Evidence suggests that lower levels of DHEA are associated with cardiovascular, cognitive, and sexual impairment in women, and the brain metabolism and the implications of D HEA treatment in postmenopausal women will be discussed.
DHEAS Levels in Obese Patients with Hashimato Thyroiditis
It has been shown that insulin increases D HEA clearance, suggesting that low DHEA levels may in fact be a consequence of insulin resistance.
Dehydroepiandrosterone: A neuroactive steroid
Dehydroepiandrosterone - is the fountain of youth drying out?
This article tries to summarize some of the most important facts achieved recently on the role of exogenous DHEA in health, disease and human well-being.
Effects of dehydroepiandrosterone (DHEA) supplementation on cortisol, leptin, adiponectin, and liver enzyme levels: A systematic review and meta‐analysis of randomised clinical trials
Meta‐analyse the effects of DHEA supplementation on circulating levels of cortisol, liver enzymes, and adipokines in patients with altered cortisol levels and found no compelling for liver safety.
Effect of dehydroepiandrosterone supplementation on fatty acid and hormone levels in patients with X‐linked adrenoleucodystrophy
Most patients have a primary adrenocortical insufficiency with low levels of cortisol and dehydroepiandrosterone (DHEA) and its sulphate ester (D HEA‐S), collectively called DHEA(S).
Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer's Disease.
Despite mixed results, the findings of various preclinical studies are generally supportive of the involvement of DHEA and DHEAS in the pathophysiology of Alzheimer's disease, showing some promise for potential benefits of these neurosteroids in the prevention and treatment.


Cortisol, dehydroepiandrosterone (DHEA), and DHEA sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age.
The relation between levels in the blood and CSF differ for each of these three neuroactive steroids, showing the brain is exposed to relatively high levels of DHEA and DHEAS during later childhood and early adulthood but to relatively or absolutelyhigh levels of cortisol during infancy and older age.
Dehydroepiandrosterone and its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain cell cultures
It is shown that a supplement of as little as 10−8 M D HEA or DHEA‐S greatly increases neuronal survival and differentiation and reduces astroglial proliferation rates in mouse brain cells in cultures.
Characterization and measurement of dehydroepiandrosterone sulfate in rat brain.
It is proposed that Ia formation or accumulation in the rat brain depends on in situ mechanisms unrelated to the peripheral endocrine gland system.
Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study.
The continuing decrease of DHEAS serum concentration with age is confirmed, more in men than in women, even if men retain higher levels, and correlations observed here between functional and psychological status and endogenous steroid serum concentrations are observed.
Neurosteroids do not regulate proopiomelanocortin-gene expression in pituitary cells.
The results suggest that neurosteroids do not control POMC-gene expression at the level of the pituitary corticotroph and exclude significant effects of these compounds at the glucocorticoid receptor.
Dehydroepiandrosterone (DHEA) treatment of depression