Dehydroepiandrosterone – a neurosteroid

@article{Friess2000DehydroepiandrosteroneA,
  title={Dehydroepiandrosterone – a neurosteroid},
  author={Elisabeth Friess and Thomas Schiffelholz and Thomas Steckler and Arthur Steiger},
  journal={European Journal of Clinical Investigation},
  year={2000},
  volume={30}
}
Dehydroepiandrosteone (DHEA) and its sulfate ester (DHEAS) are the major secretory products of the human adrenal glands and serve as precursors for both androgenic and estrogenic steroids. DHEA/S concentrations are particularly high in the brain, and DHEA/S and related steroids can be synthesized de novo in brain glial cells. Therefore, the term ‘neurosteroids’ has been coined for these compounds. 
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TLDR
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TLDR
It is shown that a supplement of as little as 10−8 M D HEA or DHEA‐S greatly increases neuronal survival and differentiation and reduces astroglial proliferation rates in mouse brain cells in cultures.
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TLDR
It is proposed that Ia formation or accumulation in the rat brain depends on in situ mechanisms unrelated to the peripheral endocrine gland system.
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TLDR
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TLDR
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