Dehydroepiandrosterone (DHEA) such as 17beta-estradiol prevents MPTP-induced dopamine depletion in mice.

@article{DAstous2003DehydroepiandrosteroneS,
  title={Dehydroepiandrosterone (DHEA) such as 17beta-estradiol prevents MPTP-induced dopamine depletion in mice.},
  author={Myreille D'Astous and Marc P. Morissette and Bastien Tanguay and Sophie Callier and Th{\'e}r{\`e}se Di Paolo},
  journal={Synapse},
  year={2003},
  volume={47 1},
  pages={10-4}
}
Previous work from our laboratory has shown prevention of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal dopamine (DA) depletion in mice by 17beta-estradiol, progesterone, and raloxifene. Dehydroepiandrosterone (DHEA), a neurosteroid, was shown to have neuroprotective activities in various paradigms of neuronal death but its effect in vivo in mice on MPTP toxicity has not been reported. We investigated the effects of 17beta-estradiol (2 microg/day) and DHEA (3 mg/day) for… CONTINUE READING