Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity

  title={Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity},
  author={Arthur G. Schwartz and Laura L. Pashko},
  journal={Ageing Research Reviews},
Dehydroepiandrosterone increased oxidative stress in a human cell line during differentiation
Findings indicate that DHEA acts both as an antioxidant and as a pro-oxidant in a human promyelocytic leukaemia cell line, HL60, during the differentiation to neutrophil-like cell.
Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue.
Evidence is provided that some of the anti-diabetic effects of DHEA may be caused through inhibition of the local amplification of glucocorticoids by 11beta-HSD1 in adipose tissue.
Dehydroepiandrosterone improves hepatic antioxidant reserve and stimulates Akt signaling in young and old rats
DHEA Treatment Effects on Redox Environment in Skeletal Muscle of Young and Aged Healthy Rats
The results show that chronic DHEA administration to 3 and 24-months-old rats may not present positive effects regarding the redox environment in skeletal muscle without modulation of pro-survival Akt kinase.
A spectrum of serum dehydroepiandrosterone and sex steroid levels in postmenopausal women.
  • J. Pru
  • Biology, Medicine
  • 2011
DHEA levels with age are associated with a number of menopausal conditions that include poor libido, vasomotor symptoms, osteoporosis, atrophy of female reproductive tissues, cardiovascular disease, and dementia, among others, and DHEA supplementation was found to marginally improve well-being and sexual function in some studies but not others.
Plasma levels of 7-hydroxymetabolites of dehydroepiandrosterone in healthy Central European aging men
Abstract Evidence has been accumulating that 7-hydroxyepimers of dehydroepiandrosterone may act as locally active immunomodulatory and immunoprotective agents, counteracting the actions of


Therapeutic Effects of Dehydroepiandrosterone (DHEA) in Diabetic Mice
The steroid significantly moderated the severity of the ensuing diabetes and prevented the other pathogenic changes and effected a rapid remission of hyperglycemia, a preservation of beta-cell structure and function, and an increased insulin sensitivity as measured by glucose tolerance tests.
Cancer chemoprevention with the adrenocortical steroid dehydroepiandrosterone and structural analogs
Using the mouse two‐stage skin tumorigenesis model, adrenalectomy completely reverses the anti‐hyperplastic and antitumor‐promoting effects of food restriction, suggesting that food restriction stimulates enhanced levels of adrenocortical steroids, which in turn mediate the tumor‐inhibitory effect of underfeeding.
Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA)
The anti-glucocorticoid action of D HEA may explain many of the seemingly diverse biological activities of DHEA, such as its effects on stress, obesity, diabetes, immune responses, and protection against acute lethal viral infections.
Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury.
The results show that high levels of plasma DHEA inhibit the development of atherosclerosis and they provide an important experimental link to the epidemiologic studies correlating low D HEA-sulfate plasma levels with an enhanced risk of cardiovascular mortality.
Novel dehydroepiandrosterone analogues with enhanced biological activity and reduced side effects in mice and rats.
Two synthetic steroids are developed, 16 alpha-fluoro-5-androstan-17-one and 16alpha-fluoros-5 alpha-androStan- 17-one, which lack specific side-effects of DHEA treatment and demonstrate greater potency, and may have therapeutic application as drugs for humans.
The Actions of Exogenous Dehydroepiandrosterone in Experimental Animals and Humans
  • F. Svec, J. Porter
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1998
DHEA's pattern of activity represents a new class of steroid hormones, the “Regnantoids,” and further progress in the endocrinology of this family of steroids may only come when synthetic, long-acting analogs of DHEA are available for in vitro studies to allow correlations between hormone action and receptor binding.
Antihyperglycemic Effect of Dehydroepiandrosterone Analogue 16α-Fluoro-5-androsten-17-one in Diabetic Mice
The synthetic steroid, 16α-fluoro-5-androsten-17-one, is developed, which lacks the androgenic action of dehydroepiandrosterone yet has retained other biological activities of the native steroid.