Dehydroepiandrosterone's antiepileptic action in FeCl3-induced epileptogenesis involves upregulation of glutamate transporters.

@article{Mishra2013DehydroepiandrosteronesAA,
  title={Dehydroepiandrosterone's antiepileptic action in FeCl3-induced epileptogenesis involves upregulation of glutamate transporters.},
  author={Monika Mishra and Rameshwar Baliar Singh and Somnath Mukherjee and Deepak Sharma},
  journal={Epilepsy research},
  year={2013},
  volume={106 1-2},
  pages={83-91}
}
Dehydroepiandrosterone (DHEA), a neuroactive androgen steroid, has antiepileptic action in iron-induced experimental epilepsy (which models post-traumatic clinical epilepsy). In iron-induced epilepsy increased extracellular glutamate resulting from its reduced glial uptake due to the down-regulation (decreased expression) of transporters (glial and or neuronal) is active during epileptogenesis. The present study was aimed at determining whether the mechanism of antiepileptic action of DHEA… CONTINUE READING

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