Dehydrodiisoeugenol, an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages.

@article{Murakami2005DehydrodiisoeugenolAI,
  title={Dehydrodiisoeugenol, an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages.},
  author={Yukio Murakami and Masao Shoji and Atsushi Hirata and Shoji Tanaka and Ichiro Yokoe and Seiichiro Fujisawa},
  journal={Archives of biochemistry and biophysics},
  year={2005},
  volume={434 2},
  pages={326-32}
}
o-Methoxyphenols such as eugenol and isoeugenol exhibit anti-oxidant and anti-inflammatory activities, but at higher concentrations act as oxidants and potent allergens. We recently demonstrated the eugenol dimer bis-eugenol to be an efficient inhibitor of lipopolysaccharide (LPS)-induced inflammatory cytokine expression in macrophages without cytotoxicity. This result suggested that dimer compound of o-methoxyphenols may possess anti-inflammatory activity. Thus, we further synthesized… CONTINUE READING
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