Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification

@inproceedings{Holmes2002DehydroascorbicAU,
  title={Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification},
  author={Melanie E. Holmes and James Mwanjewe and Sue E. Samson and James V. Haist and John X. Wilson and Scott J. Dixon and Morris Karmazyn and Ashok Kumar Grover},
  year={2002}
}
  • Melanie E. Holmes, James Mwanjewe, +5 authors Ashok Kumar Grover
  • Published 2002
  • Chemistry
  • Dehydroascorbic acid (DHAA) enters cells via Na'-independent glucose transporters (GLUT) and is converted to ascorbate. However, we found that Na + removal inhibited [ 1 4 C]DHAA uptake by smooth-muscle cells cultured frompig coronary artery. The uptake was examined for 2 12 min at 10 200 μM DHAA in either the presence of 134 mM Na + or in its absence (N-methyl D-glucamine, choline or sucrose replaced Na + ). This inhibition of DHAA uptake by Na + removal was paradoxical because it was… CONTINUE READING

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