Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke.

Abstract

Neuronal injury in ischemic stroke is partly mediated by cytotoxic reactive oxygen species. Although the antioxidant ascorbic acid (AA) or vitamin C does not penetrate the blood-brain barrier (BBB), its oxidized form, dehydroascorbic acid (DHA), enters the brain by means of facilitative transport. We hypothesized that i.v. DHA would improve outcome after… (More)

Topics

Cite this paper

@article{Huang2001DehydroascorbicAA, title={Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke.}, author={Joseph Huang and David Agus and Christopher J. Winfree and Szil{\'a}rd Kiss and Werner Mack and R. A. McTaggart and Tanvir F. Choudhri and Louis J. Kim and J D Mocco and David J. Pinsky and Warren Fox and Rebecca Israel and Tristan A Boyd and David W. Golde and E Sander Connolly}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2001}, volume={98 20}, pages={11720-4} }