Dehydro-digitoxosides of digitoxigenin: Formation and importance for the digitoxin metabolism in the rat

@article{Schmoldt1978DehydrodigitoxosidesOD,
  title={Dehydro-digitoxosides of digitoxigenin: Formation and importance for the digitoxin metabolism in the rat},
  author={Achim Schmoldt and Christoph Rohloff},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1978},
  volume={305},
  pages={167-172}
}
  • A. SchmoldtC. Rohloff
  • Published 1 November 1978
  • Biology, Chemistry
  • Naunyn-Schmiedeberg's Archives of Pharmacology
SummaryOnly in the presence of NADPH and oxygen digitoxosides of digitoxigenin can be metabolized by rat liver microsomes. The metabolism includes 12β-hydroxylation, formation of digitoxosides less the terminal digitoxose and of lipophilic metabolites. The lipophilic metabolites of digitoxin (dt-3), digitoxigeninbis-digitoxoside (dt-2), and of — mono-digitoxoside (dt-1) are formed by oxidation of the axial OH-group of the terminal digitoxosyl yielding the corresponding dehydro-digitoxosides… 

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Für Untersuchungen des Digitoxin‐Metabolismus sollten Oxidationsprodukte von Digitoxosiden des Digitoxigenins und Digoxigenins synthetisiert werden. Bei der katalytischen Oxidation (Pt,O2) in Aceton