Dehydration of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase.

  • P R Adams, R Harrison
  • Published 1974 in The Biochemical journal

Abstract

S-(+)-3,4-Dihydroxybutylphosphonic acid, an isosteric analogue of sn-glycerol 3-phosphate, was synthesized stereospecifically and shown to be an effective substrate for rabbit muscle glycerol 3-phosphate dehydrogenase (sn-glycerol 3-phosphate-NAD(+) oxidoreductase, EC 1.1.1.8). Non-isosteric phosphonate analogues of sn-glycerol 3-phosphate showed neither substrate nor inhibitory activity with the enzyme.

Cite this paper

@article{Adams1974DehydrationOA, title={Dehydration of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase.}, author={P R Adams and R Harrison}, journal={The Biochemical journal}, year={1974}, volume={141 3}, pages={729-32} }