Dehydration-induced modulation of kappa-opioid inhibition of vasopressin neurone activity.

@article{Scott2009DehydrationinducedMO,
  title={Dehydration-induced modulation of kappa-opioid inhibition of vasopressin neurone activity.},
  author={Victoria G Scott and Valerie R. Bishop and Gareth Leng and Colin H Brown},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 23},
  pages={
          5679-89
        }
}
Dehydration increases vasopressin (antidiuretic hormone) secretion from the posterior pituitary gland to reduce water loss in the urine. Vasopressin secretion is determined by action potential firing in vasopressin neurones, which can exhibit continuous, phasic (alternating periods of activity and silence), or irregular activity. Autocrine kappa-opioid inhibition contributes to the generation of activity patterning of vasopressin neurones under basal conditions and so we used in vivo… CONTINUE READING

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