Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells.

@article{Hao2000DehydrationAA,
  title={Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells.},
  author={C M Hao and Fiona Yull and T. Blackwell and Martin K{\"o}mhoff and Linda Sue Davis and Matthew D. Breyer},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 8},
  pages={973-82}
}
Renal prostaglandin (PG) synthesis is mediated by cyclooxygenase-1 and -2 (COX1 and COX2). After dehydration, the maintenance of normal renal function becomes particularly dependent upon PG synthesis. The present studies were designed to examine the potential link between medullary COX1 and COX2 expression in hypertonic stress. In response to water deprivation, COX2, but not COX1, mRNA levels increase significantly in the renal medulla, specifically in renal medullary interstitial cells (RMICs… CONTINUE READING