Deguelin Induces Both Apoptosis and Autophagy in Cultured Head and Neck Squamous Cell Carcinoma Cells

@inproceedings{Yang2013DeguelinIB,
  title={Deguelin Induces Both Apoptosis and Autophagy in Cultured Head and Neck Squamous Cell Carcinoma Cells},
  author={Yan-li Yang and Chao Ji and Zhi-gang Bi and Chun-cheng Lu and Rong Wang and Bing Gu and Lei Cheng},
  booktitle={PloS one},
  year={2013}
}
Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annually in United States and around the world. Despite advances in the management of patients with this disease, the survival has not been significantly improved, and the search for potential alternative therapies is encouraging. Here we demonstrate that deguelin administration causes a significant HNSCC cell death. Deguelin induces both cell apoptosis and autophagy by modulating multiple signaling… CONTINUE READING