Degree of tumour vascularity correlates with drug accumulation and tumour response upon TNF-α-based isolated hepatic perfusion

@article{Etten2003DegreeOT,
  title={Degree of tumour vascularity correlates with drug accumulation and tumour response upon TNF-α-based isolated hepatic perfusion},
  author={Boudewijn van Etten and Mark Rem de Vries and Marc G. A. van Ijken and Titia E. Lans and Gunther Guetens and Gisela Ambagtsheer and Sandra T. van Tiel and Gert de Boeck and Ernst A. de Bruijn and A. M. M. Eggermont and Timo L. M. ten Hagen},
  journal={British Journal of Cancer},
  year={2003},
  volume={88},
  pages={314 - 319}
}
Isolated hepatic perfusion (IHP) with melphalan with or without tumour necrosis factor alpha (TNF-α) is currently performed in clinical trials in patients with hepatic metastases. Previous studies led to the hypothesis that the use of TNF-α in isolated limb perfusion causes specific destruction of tumour endothelial cells and thereby induces an increased permeability of tumour vasculature. However, whether TNF-α contributes to the therapeutic efficacy in IHP still remains unclear. In an in vivo… CONTINUE READING
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