Degree of antigen adsorption in the vaccine or interstitial fluid and its effect on the antibody response in rabbits.

@article{Chang2001DegreeOA,
  title={Degree of antigen adsorption in the vaccine or interstitial fluid and its effect on the antibody response in rabbits.},
  author={Michele F. Chang and Yi Shi and Steven L. Nail and Harm HogenEsch and Stephen B. Adams and Joe L. White and Stanley L. Hem},
  journal={Vaccine},
  year={2001},
  volume={19 20-22},
  pages={
          2884-9
        }
}
The effect of the degree of adsorption of lysozyme by aluminium hydroxide adjuvant on the immune response in rabbits was studied. The surface charge of the adjuvant was modified by pretreatment with phosphate anion to produce five vaccines having degrees of adsorption ranging from 3 to 90%. The degree of adsorption of vaccines exhibiting 3, 35 or 85% adsorption changed to 40% within 1 h after each vaccine was mixed with sheep interstitial fluid to simulate subcutaneous administration. The mean… CONTINUE READING

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Antigenic fingerprinting of diphtheria toxoid adsorbed to aluminium phosphate.

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