Degree and time sequence of hypothermic protection against experimental ischemic acute renal failure.

@article{Zager1989DegreeAT,
  title={Degree and time sequence of hypothermic protection against experimental ischemic acute renal failure.},
  author={Richard A Zager and Dennis J. Gmur and Charles R Bredl and Molly Eng},
  journal={Circulation research},
  year={1989},
  volume={65 5},
  pages={1263-9}
}
The purpose of this study was to assess the degree, time sequence, and biochemical correlates of hypothermic protection against ischemic acute renal failure. Rats subjected to 40 minutes of bilateral renal artery occlusion (RAO) were made mildly hypothermic (32 degrees-33 degrees C, by cold saline peritoneal lavage) during the following time periods: 1) RAO only, 2) reperfusion only (beginning at 0, 15, 30, or 60 minutes after RAO and maintained for 45 minutes), or 3) during and after (0-45… CONTINUE READING