Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

@article{Bossi1999DegranulationPA,
  title={Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells},
  author={Giovanna Bossi and Gillian M Griffiths},
  journal={Nature Medicine},
  year={1999},
  volume={5},
  pages={90-96}
}
Fas ligand (FasL) triggers apoptosis during cytotoxicity mediated by cytotoxic T lymphocytes and during immune downregulation. The ability of T cells and natural killer cells to trigger apoptosis through this mechanism is controlled by the cell surface expression of FasL (ref. 2). Because FasL expression is upregulated on activation, FasL was thought to be delivered directly to the cell surface. Here we show that newly synthesized FasL is stored in specialized secretory lysosomes in both CD4… CONTINUE READING
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