Degrading devices: invadosomes in proteolytic cell invasion.

  title={Degrading devices: invadosomes in proteolytic cell invasion.},
  author={Stefan Linder and Christiane Wiesner and Mirko Himmel},
  journal={Annual review of cell and developmental biology},
Podosomes and invadopodia, collectively known as invadosomes, are cell-matrix contacts in a variety of cell types, such as monocytic cells or cancer cells, that have to cross tissue barriers. Both structures share an actin-rich core, which distinguishes them from other matrix contacts, and are regulated by a multitude of signaling pathways including RhoGTPases, kinases, actin-associated proteins, and microtubule-dependent transport. Invadosomes recruit and secrete proteinases and are thus able… CONTINUE READING
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