Degraded Carrageenan Causing Colitis in Rats Induces TNF Secretion and ICAM-1 Upregulation in Monocytes through NF-κB Activation

@inproceedings{Benard2010DegradedCC,
  title={Degraded Carrageenan Causing Colitis in Rats Induces TNF Secretion and ICAM-1 Upregulation in Monocytes through NF-κB Activation},
  author={Claudine Benard and Antonietta Cultrone and Catherine Michel and Carlos Rosales and J P Segain and Marc Lahaye and J. -P. Galmiche and Christine Cherbut and Herv{\'e} M Blotti{\`e}re},
  booktitle={PloS one},
  year={2010}
}
Carrageenan (CGN) is a high molecular weight sulphated polysaccharide derived from red seaweeds. In rodents, its degraded forms (dCGN) can induce intestinal inflammation associated with macrophage recruitment and activation. The aim of this study was: 1) to analyze the size-dependent effects of dCGN on colon inflammation in vivo, and 2) to correlate these effects with monocyte/macrophage proliferation, cytokine production and expression of various cell surface antigens including ICAM-1 adhesion… CONTINUE READING
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