Degradative action of reactive oxygen species on hyaluronan.

@article{olts2006DegradativeAO,
  title={Degradative action of reactive oxygen species on hyaluronan.},
  author={Ladislav {\vS}olt{\'e}s and Raniero Mendichi and Grigorij Kogan and J{\"u}rgen Schiller and Monika Stankovsk{\'a} and Juergen Arnhold},
  journal={Biomacromolecules},
  year={2006},
  volume={7 3},
  pages={
          659-68
        }
}
Many human diseases are associated with harmful action of reactive oxygen species (ROS). These species are involved in the degradation of essential tissue or related components. One of such components is synovial fluid that contains a high-molecular-weight polymer--hyaluronan (HA). Uninhibited and/or inhibited hyaluronan degradation by the action of various ROS has been studied in many in vitro models. In these studies, the change of the molecular weight of HA or a related parameter, such as HA… CONTINUE READING
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