Degradation signals in the lysine-asparagine sequence space.

@article{Suzuki1999DegradationSI,
  title={Degradation signals in the lysine-asparagine sequence space.},
  author={Takeo Suzuki and Alexander Varshavsky},
  journal={The EMBO journal},
  year={1999},
  volume={18 21},
  pages={6017-26}
}
The N-degrons, a set of degradation signals recognized by the N-end rule pathway, comprise a protein's destabilizing N-terminal residue and an internal lysine residue. We show that the strength of an N-degron can be markedly increased, without loss of specificity, through the addition of lysine residues. A nearly exhaustive screen was carried out for N-degrons in the lysine (K)-asparagine (N) sequence space of the 14-residue peptides containing either K or N (16 384 different sequences). Of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Similar Papers

Loading similar papers…