Degradation of unmethylated miRNA/miRNA*s by a DEDDy-type 3′ to 5′ exoribonuclease Atrimmer 2 in Arabidopsis

  title={Degradation of unmethylated miRNA/miRNA*s by a DEDDy-type 3′ to 5′ exoribonuclease Atrimmer 2 in Arabidopsis},
  author={Xiaoyan Wang and Yuan Wang and Yongchao Dou and Lu Chen and Junli Wang and Ning Jiang and Chunce Guo and Qingqing Yao and Chizao Wang and L. Liu and Bin Yu and Binglian Zheng and J. A. Chekanova and J. Ma and Guodong Ren},
  journal={Proceedings of the National Academy of Sciences},
  pages={E6659 - E6667}
  • Xiaoyan Wang, Yuan Wang, +12 authors Guodong Ren
  • Published 2018
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
Significance The steady-state levels of miRNAs are under sophisticated control to ensure their proper functions such as development and responses to environmental stimuli. Nevertheless, enzymes responsible for the degradation of various forms of unmethylated miRNAs remain enigmatic, which largely impedes our understanding of miRNA homeostasis and active turnover. Here we report a 3′ to 5′ exoribonuclease Atrimmer 2 that may degrade unmethylated miRNAs in their miRNA/miRNA* duplex status, at… Expand
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