Degradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system.

@article{Khlkamp2005DegradationOT,
  title={Degradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system.},
  author={Thomas K{\"u}hlkamp and Verena Keitel and Angelika Helmer and Dieter H{\"a}ussinger and Ralf Kubitz},
  journal={Biological chemistry},
  year={2005},
  volume={386 10},
  pages={1065-74}
}
The sodium taurocholate cotransporting polypeptide (Ntcp, Slc10a1) is the major uptake system for bile acids into liver cells. This study investigated the degradation of rat Ntcp and human NTCP by the ubiquitin-proteasome system (UPS). In stably transfected HepG2 cells, rat Ntcp was complex-glycosylated and localized at the plasma membrane. Inhibition of proteasomes by MG-132 or lactacystin led to the accumulation of intracellular Ntcp, a process dependent on de novo protein synthesis… CONTINUE READING

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