Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR.

@article{MarcoUrrea2010DegradationOT,
  title={Degradation of the drug sodium diclofenac by Trametes versicolor pellets and identification of some intermediates by NMR.},
  author={Ernest Marco-Urrea and M{\'i}riam P{\'e}rez-Trujillo and Carles Cruz-Morat{\'o} and Gl{\`o}ria Caminal and Teresa Vicent},
  journal={Journal of hazardous materials},
  year={2010},
  volume={176 1-3},
  pages={
          836-42
        }
}
Degradation of diclofenac sodium, a nonsteroidal anti-inflammatory drug widely found in the aquatic environment, was assessed using the white-rot fungus Trametes versicolor. Almost complete diclofenac removal (> or = 94%) occurred the first hour with T. versicolor pellets when the drug was added at relatively high (10 mg L(-1)) and environmentally relevant low (45 microg L(-1)) concentrations in a defined liquid medium. In vivo and in vitro experiments using the cytochrome P450 inhibitor 1… CONTINUE READING
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