Degradation of spectrin and ankyrin in the ischemic rat kidney.

  title={Degradation of spectrin and ankyrin in the ischemic rat kidney.},
  author={Richard Doctor and Vann Bennett and Lazaro J. Mandel},
  journal={The American journal of physiology},
  volume={264 4 Pt 1},
This study investigates ischemia-induced degradation of the spectrin-based cytoskeleton in rat brain, heart, and kidney. Spectrin, in conjunction with ankyrin, structurally supports the plasma membrane and sequesters integral membrane proteins. After 60 and 120 min of ischemia, brain tissue displayed both spectrin and ankyrin breakdown. The spectrin fragmentation pattern is similar to previously reported ischemia-induced calpain I proteolysis of spectrin in N-methyl-D-aspartate receptor… CONTINUE READING
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