Degradation of proteins within the endoplasmic reticulum.

  title={Degradation of proteins within the endoplasmic reticulum.},
  author={Juan S Bonifacino and Jennifer Lippincott-Schwartz},
  journal={Current opinion in cell biology},
  volume={3 4},
Certain newly synthesized proteins within the endoplasmic reticulum undergo rapid turnover by a non-lysosomal proteolytic pathway. Biochemical and morphological evidence has suggested that these proteins never leave the endoplasmic reticulum before they are degraded. The mechanism(s) for the selective targeting of proteins for degradation within the… CONTINUE READING