Degradation of protein disulphide bonds in dilute alkali.


The degradation of S--S bonds in 0.2 M-NaOH at 25 degrees C was studied for a series of proteins and simple aliphatic disulphide compounds, by using cathodic stripping voltammetry, ion-selective-electrode potentiometry, spectrophotometry and ultrafiltration. The disulphide bonds that dissociated in 0.2 M-NaOH were usually those that are solvent accessible… (More)


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@article{Florence1980DegradationOP, title={Degradation of protein disulphide bonds in dilute alkali.}, author={T M Florence}, journal={The Biochemical journal}, year={1980}, volume={189 3}, pages={507-20} }