Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition.

@article{Park1995DegradationOP,
  title={Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition.},
  author={Tae Gwan Park},
  journal={Biomaterials},
  year={1995},
  volume={16 15},
  pages={1123-30}
}
The in vitro degradation behaviour of a wide range of poly(D,L-lactic-co-glycolic acid) (PLGA) has been examined in terms of degree of degradation and morphological change during an incubation period of up to 53 d. Gel permeation chromatography and differential scanning calorimetry were employed to characterize their degradation profiles. It was found that amorphous PLGA exhibited a transient multiple crystallization behaviour of D- or L-lactic acid oligomers during degradation. This indicated… CONTINUE READING

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