Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex.

@article{Querido2001DegradationOP,
  title={Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex.},
  author={Emmanuelle Querido and Paola Blanchette and Qin Yan and Takumi Kamura and Maureen Morrison and Dominique Boivin and William G Kaelin and Ronald C. Conaway and Joan W Conaway and Philip E. Branton},
  journal={Genes & development},
  year={2001},
  volume={15 23},
  pages={3104-17}
}
Although MDM2 plays a major role in regulating the stability of the p53 tumor suppressor protein, other poorly understood MDM2-independent pathways also exist. Human adenoviruses have evolved strategies to regulate p53 function and stability to permit efficient viral replication. One mechanism involves adenovirus E1B55K and E4orf6 proteins, which collaborate to target p53 for degradation. To determine the mechanism of this process, a multiprotein E4orf6-associated complex was purified and shown… CONTINUE READING
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