Degradation of oxytocin by the human placenta: effect of selective inhibitors.

@article{Mizutani1992DegradationOO,
  title={Degradation of oxytocin by the human placenta: effect of selective inhibitors.},
  author={S. Mizutani and H. Yokosawa and Y. Tomoda},
  journal={Acta endocrinologica},
  year={1992},
  volume={127 1},
  pages={
          76-80
        }
}
The hydrolysis of oxytocin by human placental subcellular fractions was studied in the presence of selective inhibitors by measuring liberated amino acids by high performance liquid chromatography (HPLC). Oxytocin degradation by microsomal and lysosomal fractions was inhibited by bestatin, amastatin and puromycin. The IC50 values of these inhibitors on oxytocin degradation by both fractions were similar to those of these inhibitors on the human placental aminopeptidase M measured by L-Leu-p… Expand
6 Citations
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