Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase.

@article{Belaaouaj2000DegradationOO,
  title={Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase.},
  author={Abderrazzaq Belaaouaj and Kwang Soo Kim and Steven D Shapiro},
  journal={Science},
  year={2000},
  volume={289 5482},
  pages={1185-8}
}
In determining the mechanism of neutrophil elastase (NE)-mediated killing of Escherichia coli, we found that NE degraded outer membrane protein A (OmpA), localized on the surface of Gram-negative bacteria. NE killed wild-type, but not OmpA-deficient, E. coli. Also, whereas NE-deficient mice had impaired survival in response to E. coli sepsis, as compared to wild-type mice, the presence or absence of NE had no influence on survival in response to sepsis that had been induced with OmpA-deficient… CONTINUE READING

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