Degradation of humoral host defense by Candida albicans proteinase.

  title={Degradation of humoral host defense by Candida albicans proteinase.},
  author={Hidenori Kaminishi and Hideo Miyaguchi and T Tamaki and Naoko Suenaga and Makoto Hisamatsu and I Mihashi and Hisao Matsumoto and Hidekatsu Maeda and Yasushi Hagihara},
  journal={Infection and immunity},
  volume={63 3},
The effect of an extracellular proteinase from the pathogenic yeast Candida albicans on the bactericidal and opsonizing activities of human serum was studied. The ability of human polymorphonuclear leukocytes to kill Staphylococcus aureus was greatly reduced when the bacteria were opsonized with human serum treated with the proteinase. The reduction in the opsonizing activity of human serum was attributed to degradation of the Fc portion of immunoglobulin G by the action of C. albicans… CONTINUE READING