Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis strain 381.

@article{Carlisle2009DegradationOH,
  title={Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis strain 381.},
  author={M D Carlisle and Rupasree N Srikantha and Kim A. Brogden},
  journal={Journal of innate immunity},
  year={2009},
  volume={1 2},
  pages={118-22}
}
Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins and some antimicrobial peptides. In this study, we show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 min. This observation suggests that proteases from P. gingivalis degrade defensins and this activity could abrogate defensin-related innate immune functions. 

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Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis strain 381

  • M. D. Carlisle, R. N. Srikantha, K. A. Brogden
  • Journal of Innate Immunity
  • 2009
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