Degradation of hepatic stearyl CoA delta 9-desaturase.

  title={Degradation of hepatic stearyl CoA delta 9-desaturase.},
  author={Juris Ozols},
  journal={Molecular biology of the cell},
  volume={8 11},
  • Juris Ozols
  • Published 1997 in Molecular biology of the cell
delta 9-Desaturase is a key enzyme in the synthesis of desaturated fatty acyl-CoAs. Desaturase is an integral membrane protein induced in the endoplasmic reticulum by dietary manipulations and then rapidly degraded. The proteolytic machinery that specifically degrades desaturase and other short-lived proteins in the endoplasmic reticulum has not been identified. As the first step in identifying cellular factors involved in the degradation of desaturase, liver subcellular fractions of rats that… CONTINUE READING