Degradation of heme oxygenase-1 by the immunoproteasome in astrocytes: A potential interferon-γ-dependent mechanism contributing to HIV neuropathogenesis.

@article{Kovacsics2017DegradationOH,
  title={Degradation of heme oxygenase-1 by the immunoproteasome in astrocytes: A potential interferon-γ-dependent mechanism contributing to HIV neuropathogenesis.},
  author={Colleen Elizabeth Kovacsics and Alexander J Gill and Surendra S. Ambegaokar and Benjamin B. Gelman and Dennis L Kolson},
  journal={Glia},
  year={2017},
  volume={65 8},
  pages={
          1264-1277
        }
}
Induction of the detoxifying enzyme heme oxygenase-1 (HO-1) is a critical protective host response to cellular injury associated with inflammation and oxidative stress. We previously found that HO-1 protein expression is reduced in brains of HIV-infected individuals with HIV-associated neurocognitive disorders (HAND) and in HIV-infected macrophages, where this reduction associates with enhanced glutamate release and neurotoxicity. Because HIV-infected macrophages are a small component of the… CONTINUE READING
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