Degradation of focal adhesion proteins during nocodazole-induced apoptosis in rat-1 cells.

@article{Kook2000DegradationOF,
  title={Degradation of focal adhesion proteins during nocodazole-induced apoptosis in rat-1 cells.},
  author={Seunghyi Kook and Sang Ryeol Shim and Jung Im Kim and J. Ahnn and Yong Keun Jung and Sang Gi Paik and Woo Keun Song},
  journal={Cell biochemistry and function},
  year={2000},
  volume={18 1},
  pages={
          1-7
        }
}
Nocodazole, a microtubule-disrupting agent, induced apoptosis in Rat-1 cells, as indicated by changes in cell morphology, DNA fragmentation, and eventual cell death. During nocodazole-induced apoptosis, normally flat cells became rounded in shape and detached from the extracellular matrix. These morphological changes appeared to be closely associated with degradation of focal adhesion proteins, including p130cas, p125(FAK) and paxillin. p130cas was also degraded in cells treated with… CONTINUE READING
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