Degradation of excess peroxisomes in mammalian liver cells by autophagy and other mechanisms

@article{Yokota2009DegradationOE,
  title={Degradation of excess peroxisomes in mammalian liver cells by autophagy and other mechanisms},
  author={Sadaki Yokota and H. Dariush Fahimi},
  journal={Histochemistry and Cell Biology},
  year={2009},
  volume={131},
  pages={455-458}
}
Here we discuss the mechanisms for the degradation of excess peroxisomes in mammalian hepatocytes which include (a) autophagy, (b) the action of peroxisomal Lon protease and (c) the membrane disrupting effect of 15-lipoxygenase. A recent study using Atg7 conditional-knock-out mice revealed that 70–80% of excess peroxisomes are degraded by the autophagic process. The remaining 20–30% of excess peroxisomes is most probably degraded by the action of peroxisomal Lon protease. Finally, a selective… CONTINUE READING

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