Degradation of cyclin A is regulated by acetylation


Cyclin A accumulates at the onset of S phase, remains high during G2 and early mitosis and is degraded at prometaphase. Here, we report that the acetyltransferase P/CAF directly interacts with cyclin A that as a consequence becomes acetylated at lysines 54, 68, 95 and 112. Maximal acetylation occurs simultaneously to ubiquitylation at mitosis, indicating… (More)
DOI: 10.1038/onc.2009.127


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