Degradation of collagen in the bone-resorbing compartment underlying the osteoclast involves both cysteine-proteinases and matrix metalloproteinases.

@article{Everts1992DegradationOC,
  title={Degradation of collagen in the bone-resorbing compartment underlying the osteoclast involves both cysteine-proteinases and matrix metalloproteinases.},
  author={Vincent E Everts and Jm. Delaisse and W. Korper and Anneke Niehof and Gilbert Vaes and Wouter Beertsen},
  journal={Journal of cellular physiology},
  year={1992},
  volume={150 2},
  pages={
          221-31
        }
}
The site of action of cysteine-proteinases (CPs) and matrix metalloproteinases (MMPs) in the degradation of bone collagen by osteoclasts was investigated by evaluating the effects of the CP-inhibitor trans-epoxy-succinyl-L-leucylamido (4-guanidino)-butane (E-64) and the MMP-inhibitor N-(3-N-benzyloxycarbonyl amino-1-R-carboxypropyl)-L-leucyl-O-methyl-L-tyrosine N-methylamide (Cl-1) in an in vitro model system of PTH-stimulated mouse calvaria. In the presence of each of the two inhibitors a… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 73 CITATIONS, ESTIMATED 82% COVERAGE

Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin K

  • BMC Research Notes
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A Mild Inhibition of Cathepsin K Paradoxically Stimulates the Resorptive Activity of Osteoclasts in Culture

Dinisha Cyril Pirapaharan, Kent Søe, +5 authors Jean-Marie Delaisse
  • Calcified Tissue International
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

FILTER CITATIONS BY YEAR

1993
2018

CITATION STATISTICS

  • 3 Highly Influenced Citations