Degradation of chromosomal DNA during apoptosis

  title={Degradation of chromosomal DNA during apoptosis},
  author={Shigekazu Nagata and Hiroko Nagase and Kohki Kawane and Naomi Mukae and Hidehiro Fukuyama},
  journal={Cell Death and Differentiation},
AbstractApoptosis is often accompanied by degradation of chromosomal DNA. CAD, caspase-activated DNase, was identified in 1998 as a DNase that is responsible for this process. In the last several years, mice deficient in the CAD system have been generated. Studies with these mice indicated that apoptotic DNA degradation occurs in two different systems. In one, the DNA fragmentation is carried out by CAD in the dying cells and in the other, by lysosomal DNase II after the dying cells are… CONTINUE READING

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